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these observations corroborate the notion that specific subtle constraints must exist whereby a particular G6PD variant has a distinctly severe clinical expression but remains compatible with life

2008 Nov;28(11):738-43

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2025 Feb 10:115317

An analysis of 9,881 MS patients in the Danish Multiple Sclerosis Registry revealed that the mortality rate from CVD was significantly higher in MS patients compared to matched controls [50], and an analysis of over 6,000 patient deaths in the Danish MS Registry revealed that 17.6 % of deaths were caused by vascular or cardiac diseases, which was the most frequently listed cause of death outside of MS itself [43]