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It's receptor affinity

According to study conducted by Adeshara et al., augmented antioxidant properties were evident following a 3-month period of metformin administration in patients with T2DM patients ( 2 Materials and methods The literature review was conducted using various databases including Scopus, Web of Science, PubMed, Directory of Open Access Journals (DOAJ), ClinicalTrials.gov, and Science Direct

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Furthermore, NRF2 was also found to regulate the expression of thioredoxin 1 (TXN1) and thioredoxin reductase 1 (TXNRD1), which can reduce oxidized protein thiols [25, 26]

It can last several months before regrowth begins