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Although early generations of ENDS did not effectively deliver nicotine to users, newer generations were engineered and modified to produce more aerosol and a more consistent nicotine yield.55 56 Studies with newer ENDS have shown that those products can generate nicotine yields comparable to, and sometimes exceeding, the nicotine yield from one tobacco cigarette (1.762.20 mg).5759 Industry-funded studies on novel ONPs suggest that those products deliver nicotine as quickly and to a similar extent as existing smokeless products.60 61 The pH of inhaled aerosol generated from ENDS and HTPs plays a large role in nicotine bioavailability

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