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Understanding these numbers helps set realistic expectations for treatment

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Semaglutide (known by brand names like Ozempic and Wegovy) is a GLP-1 receptor agonist that mimics the body's natural GLP-1 hormone to reduce appetite, slow gastric emptying, and create a prolonged feeling of fullness

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Most patients see stable or declining liver enzymes within 812 weeks, reflecting hepatic health recovery rather than drug-induced liver injury

It has been reported that there is no reduction in its secretion in patients with T2DM [13] but a nearly total loss of insulinotropic effect is observed, even at supraphysiological concentrations, implying the existence of GIP resistance [14]