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This chemical interaction not only leads to physical dependence but also results in changes in brain function, making individuals anxious or irritable when they try to quit

Acetaldehyde stimulates dopaminergic reward pathways, making cigarettes more reinforcing and habit-forming

A recent study reported a further increase up to 2023 in England [10], but it is not clear the extent to which these increases have differed by key sociodemographic groups and smoking and vaping characteristics

As discussed in detail below, Philip Morris started proceedings in February 2010 claiming that the comprehensive tobacco control measures adopted by the Government of Uruguay since 2003 violated obligations under international trade and investment arrangements

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While our disease risk estimates are based on a limited number of studies with modest quality, the likely disease burden attributable to ST is substantial