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Notably, another important cell involved in the pathogenic process of RA is the fibroblast-like synoviocytes (FLSs), and there are more available studies that examine the effects of GLP-1RAs on FLSs

10.1016/0006-8993(81)90200-6 [DOI] [PubMed] [Google Scholar] Gaveriaux-Ruff C., Kieffer B

A Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023) reported that participants receiving higher doses of retatrutide (up to 12 mg) achieved mean body weight reductions of approximately 1724% over 48 weeks

It is a legitimate modification that does not reduce long-term effectiveness

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