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Moolgavkar et al

Regarding the co-administration of bupropion with linezolid, four tools indicate an increased risk of serotonergic syndrome (agitation, mental confusion, cognitive deficits, diaphoresis, myoclonus, hyperreflexia, hypertension, palpitations, and muscle rigidity)

The additional stress may cause people to relapse or increase their smoking

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This study also indicates that cortisol may reflect a unique phenotypic manifestation of tobacco withdrawal that is separate from potentially several distinct phenotypic expressions of withdrawal across domains