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In humans, circulating E2 derives predominantly from aromatization in peripheral adipose tissues and 4060% of the total pool in women circulates bound to sex hormone-binding globulin SHBG circulation [80]

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The outcomes were all-cause mortality and the four largest contributors to smoking-related mortality: lung cancer, ischaemic heart disease (IHD), stroke and chronic obstructive pulmonary disease (COPD)