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The therapeutic potency of such compounds is directly related to their structureactivity relationships, which control their antioxidant activity, bioavailability, and bloodbrain barrier permeability

Loss of FBP1 not only sustains elevated glycolytic flux, but also destabilizes the mitochondrial membrane potential, increases ROS levels, and impairs activation of antioxidant defenses such as SOD2 [99]

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8 Weekly doses of GLP-1RAs preferentially improve fasting blood glucose levels, whereas daily or twice daily doses improve postprandial blood glucose levels to a greater degree

The pore-forming mechanism can be further categorized into two models: barrel-stave pore and toroidal pore (Kumar et al., 2018