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DiPaolo JA & Sheehe PR (1962) The combined carcinogenic effect of cigarette smoke condensate and urethan

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If a person smokes, the toxins from the cigarette enters the bloodstream and ends up being carried into the kidney for filtration

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show similar up-regulation of PanIN lesion formation, inflammation, fibrosis and stellate cells activation in the same animal model, but with a shorter exposure to cigarette smoke (6 weeks) (38)

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