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How doctors can test for nicotine Nicotine and its byproduct cotinine can be detected through several types of tests, each with its own detection window: Urine tests are the most common, often detecting nicotine use within the past three to four days and up to three weeks in heavy users, according to Verywell Mind

This makes it favourable for those who prefer strong tobacco flavours on their smokeless tobacco

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However, the full impact is usually seen after months or years of continuous use

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[3] [6] This phase is associated with a fall in progestogen levels, mucosal proliferation and keratinization