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It is relevant to note that, in three studies [47, 54, 57], a reduction in neutropenia was observed in smokers, suggesting a reduced toxicity on blood cells, which could also lead to a reduced toxicity on neoplastic cells, with a consequent reduction in the anti-tumor effect of the drug, increasing the probability of failure of therapy
Psychopharmacology 236 (2), 573580
Hence, the odds of having ANA for smokers versus nonsmokers would be smaller in Period 2 than in Period 1 (as we observed)
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