Despite efforts by Lilly and Novo to ramp up production, shortages remain, particularly for the initial starter doses of Wegovy, which is still listed as being in shortage by the FDA
If the vial has been out of the fridge for extended periods, exposed to direct sunlight, or frozen, the formulation may be compromised regardless of its color
Common issues include gastrointestinal discomfort like nausea and diarrhea
However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)
Although the trial population included diet-controlled GDM (10%), the results showed that IOL resulted in an increased rate of spontaneous vaginal delivery (RR 1.14, 95% Cl 1.011.29), a decrease in the rate of shoulder dystocia (RR 0.32 95% Cl 0.120.85) and an increase in the rate of neonatal hyperbilirubinemia (169)
Dosage, Use, and Safety Considerations When we look at using Melanotan peptides, its important to understand how they are given, how much people take, possible health risks, and what the law and science say about them