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The proposed mechanism is that MOTS-c interacts with the STAT3 transcription factor via its putative SH2 binding motif (YIFY region), thereby reducing STAT3s transcriptional activity and promoting myotube formation

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Scintigraphy remains the gold-standard technique for quantifying gastric emptying and allows measurement of both solid and liquid emptying, potentially concurrently, although frequently only solid emptying is assessed

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