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Cannabis and nicotine share similar use contexts, meaning they can be used with similar products or devices (such as a flavored vape pen) and involve comparable behavioral patterns

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Furthermore, with reference to its fellow anti-4 integrin molecule natalizumab, smoking was associated with a higher likelihood of anti-natalizumab antibody development in multiple sclerosis patients and smoking was associated with higher risk of relapse in multiple sclerosis patients on natalizumab [25,26]

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