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A casecontrol study from Nepal reported an association between chewing tobacco and HNC (OR = 2.39

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You have less of a chance of success if you quit cold turkey than if you try to use a combination of other methods

Similarity in Oral Microbiome Composition of OSCC and Healthy Smokeless-Tobacco-Consuming Samples Since the microbial population structure in soft and hard tissues show substantial differences, we analyzed the microbiome composition in soft tissues (buccal sites) separately

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