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Spoiler alert: theres no one-size-fits-all answer

NCT01039272

This can include things like stress, certain places, or social situations

An advantage of this approach is that the denominator would represent sales that are ultimately dispensed in retail community pharmacy settings and in outpatient settings (whereas, as mentioned previously, unit reporting under the MDRP represents units typically dispensed only in the retail community pharmacy setting)

But biology is only one part of the explanation, as Tidey will tell you

These include drinking more than intended, unsuccessful attempts to cut down, craving, neglecting major obligations, and continued use despite problems