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Studies have indicated that heroin reduces mitochondrial potential and alters the Bcl-2/Bax ratio, thereby affecting cell survival (Solis et al., 2017)
10.1016/j.cell.2012.03.042 18 DongS.LiX.XuG.ChenL.ZhaoJ
These effects, in combination, support weight management and glycemic control in patients with obesity and type 2 diabetes ( 1, 3 )
Andersson, Emmanuel Shapira, Biochemical and clinical response to hydroxocobalamin versus cyanocobalamin treatment in patients with methylmalonic acidemia and homocystinuria (cblC), The Journal of Pediatrics, Volume 132, Issue 1, January 1998, Pages 121-124, ISSN 0022-3476, Okuda K, Yashima K, Kitazaki T, Takara I