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Let's clear the smoke and look at the facts

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In contrast, the rates across England and the region have steadily decreased over this time period

It is often used in pipe tobacco but can add an interesting twist to cigarette blends

Methods Data sources and searches We did a systematic literature review of English language articles published between 1946 and May 2015 in Medline (MOOSE guidelines13) that reported the association between cigarette consumption and coronary heart disease and stroke