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This has the potential to result in a reservation to prescribing actively smoking patients dose intensification of biologics for secondary loss of response, given the expense and resource implications, especially if the individual is unable or unwilling to quit smoking

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Other Factors: Some studies have found links between diverticular disease and other environmental factors such as smoking, obesity, physical inactivity, and certain medications including non-steroidal anti-inflammatory drugs (NSAIDS), opiates, and steroids

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