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The PM researchers justified their use of TPM normalization on the grounds that We choose TPM as our basis of comparison to be consistent with the animal and in vitro studies presented in this series of publications and because Since consumers choose to smoke cigarettes according to the tar delivery and taste, we chose to normalize the data to the TPM yield to reveal the effect of ingredients which contribute to the taste [129]

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Surgeon General had found and declared a causal link between smoking and lung cancer

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Fortunately, there have been active efforts for many years to warn of the dangers of smoking and to assist individuals to quit

To begin with, from the standpoint of harm reduction, the question is not whether e-cigarettes pose no health risks at all (except perhaps for the subject of initiation by youth, a subject to which I will return below)