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Images were analyzed using standard preprocessing procedures (slice time-corrected, motion-corrected, resampled to 3 3 3 isotropic voxels, normalized to Montreal Neurological Institute space, spatially smoothed using a 6-mm FWHM Gaussian filter, and temporally filtered using a high-pass filter with 1/120 Hz cutoff frequency)

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This mechanism has also been implicated in emphysema, a chronic obstructive pulmonary disease characterized by alveolar destruction [16]