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58 Antioxidant-enzyme interaction in diabetes Diabetes, as a metabolic disorder, is associated with an imbalance between the generation of ROS and the antioxidant defense system

Chlorogenic acid inhibited APAP-induced activation of caspase-3 and caspase-7, JNK, ERK1/2, and upstream molecular signaling of p38 MAPKs in animals, including apoptosis signal-regulated kinase 1 (ASK1), c-Raf, and Mitogen-activated protein kinases MEK1/2, MKK3/6 and MKK4 (Wei et al., 2018)

Long-term maintenance dosing remains stable for many patients once therapeutic goals are achieved, though periodic reassessment ensures continued appropriateness of therapy

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10.1634/THEONCOLOGIST.2010-0256 38 LargM

The discovery of new diseases by utilizing laboratory data for clinical research