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Both products significantly increased plasma nicotine and exhaled CO and significantly reduced the reported urge to smoke

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EV-mediated cargo transfer to recipient cells affects many stages of cancer progression through communication between the cancer cells and the surrounding tumor microenvironment, such as the promotion of myofibroblast differentiation 33 , activation of proliferative and angiogenic pathways 34 , and initiation of pre-metastatic sites 35,36

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