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During this period, the brain's dopamine levels drop, leading to irritability, anxiety, and cravings

Altogether, smoking is the most important modifiable risk factor for cardiovascular disease, a major risk factor for cardiovascular morbidity and mortality, and is considered to be the leading preventable cause of death in the world

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[4] Netherlands [edit] Shag tobacco has always had a high market-share in the Dutch tobacco-market, although it is declining

This side effect is fairly rare

The relaxing effect comes from the nicotine