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Prior studies in cancer cell lines showed that ABHD11 deficiency leads to 2-OG accumulation, which drives the formation of the l-enantiomeric ( S) form of 2-hydroxyglutarate (2-HG) and subsequent inactivation of 2-OGDDs involved in the HIF pathway (prolyl hydroxylases, PHDs), histone marks (for example, lysine demethylases, KDMs) and DNA methylation (for example, ten-eleven translocation,TET enzymes) 16,22,23
A.ZhongJ.PinedaC.YingZ.et al (2011a)
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Psychopharmacology (Berl) 104 : 255259 Papp M, Klimek V, Willner P
McVean, M., Preclinical Development to IND: Drugs, Biologics, Cellular/Gene Therapies and Vaccines, PreClinical Research Services, Inc
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