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Another possible cause of this difference might be the relatively small sample size in Yu et al .s study 5 (only 16 smokers and 16 non-smokers)

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All procedures and the experimental design were approved by the Ethical Committee for Animal Research of the Federal University of Ouro Preto (Protocol n 2015/35), according to the Brazilian Society of Neuroscience and Behaviour and the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals (8th edition, 2011)

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References American Lung Association Information For more information about quitting smoking and how to access Freedom From Smoking, visit the American Lung Association website at Lung.org/ffs or call the free Lung HelpLine at 1-800-LUNGUSA (1-800-586-4872)