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On the other hand, substance use, including nicotine exposure, may cause damage to the brain and accelerate brain aging potentially through its neurotoxic properties, indirectly exacerbated by excessive smoking 8,10
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In addition, smokeless tobacco altered the oral microbiome in OSCC patients, significantly enriching genera such as Staphylococcus , Fusobacterium , and Campylobacter , known for producing tobacco-specific nitrosamines
Int J Neuropsychopharmacol 15 : 989994
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