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The simple answer to this fascinating question is the addictive chemical nicotine

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To date, relatively little research has been conducted on the health effects of e-cigarettes, with mostly minor side effects of mouth irritation, dry cough, nausea and vomiting reported with little or no evidence of serious adverse events [3]

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Acknowledgements The authors gratefully acknowledge Fadwa Shokry Elbaz for her expertise in designing and illustrating the figures presented in this manuscript