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In addition to human breast tumors, IFP increases in experimental models of breast cancer, such as severe combined immunodeficient mice bearing highly invasive, triple-negative MDA-MB-231 human breast cancer tumors [20] and BN472 rat mammary carcinomas [21]

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Serious but rare: Pancreatitis, gallbladder disease, kidney issues, and risk of thyroid C-cell tumors in patients with certain thyroid histories

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robust human clinical trial evidence remains limited