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When Vyvanse and Cannabis Use Becomes a Problem Polysubstance use using more than one substance regularly, whether intentionally or not complicates both the clinical picture and the path to stopping

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This is supported by findings that direct hippocampal infusion of the benzodiazepine midazolam normalizes increased dopamine neuron firing in the VTA of adult MAM rats [33]

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In fact, the deeper inhalation of smoke to compensate for reduced nicotine may allow more tar and other harmful substances to reach deeper into the lungs, potentially exacerbating respiratory conditions

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