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Samuel VT, Liu ZX, Wang A, Beddow SA, Geisler JG, Kahn M, Zhang XM, Monia BP, Bhanot S, Shulman GI (2007) Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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In other words, coffee can make you pee more, leading to or worsening dehydration

Roberto Prez-Torrado, Consejo Superior de Investigaciones Cientficas (CSIC), Spain

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Mol Psychiatry 26:54815503