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Such a reduction in sample size results in lower precision of the estimate shown by the widening of confidence intervals and the reduction of p-value significance

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Estrogen is transported throughout the body, taken into cells, and binds to estrogen receptors in the cell nucleus

They argue that, just as tobacco is not simply a 'nicotine delivery device' but has a delivery system designed to maximize its appeal, ultra-processed foods are not simply 'nutritional sources' but are highly engineered products optimized for pleasure