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Citing the science, the letter notes that Independent evidence reviews in the United Kingdom, the United States, France, Germany have repeatedly distinguished vaping from smoking while also emphasising that vaping is not risk-free. The experts stress that ignoring the scientific differences between products risks having an impact opposite to the goal to achieve less than 5% tobacco use by 2040. If Brussels now legislates on the fiction that all nicotine products are materially the same, it risks protecting the cigarette market rather than shrinking it. That would be a profound public health mistake. This matters because Europe says it wants a tobacco-free generation, defined by the Commission as less than 5% tobacco use by 2040

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In 2020, an estimated 4.5 million middle and high school students used tobacco products

The tissue blocks were then fixed in 1% osmic acid, dehydrated with ethanol and acetone gradients, and embedded in epoxy resin and propylene oxide overnight