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Long-lasting (chronic) minor stress may lead to proinflammatory responses via short-lived surges of hormones and neurotransmitters, yet major stress might lead to massive, long-lived release of stress-axe mediators of the hypothalamicpituitaryadrenal axis (norepinephrine, cortisol, and so forth), resulting in anti-inflammatory responses [94]

Instead of NSAIDs, patients can opt for alternative medications like acetaminophen, tramadol, or other non-steroidal anti-inflammatory medications that are easier on the stomach

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