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This has been accompanied by substantial death and disability directly attributable to tobacco products, to the point where smoking is the leading cause of disease burden in many countries.37 Beginning with the seminal work of Doll and Hill8 in the UK and Hammond and Horn9 in the USA, which provided early, compelling evidence on how persistent smoking affects health and survival, numerous studies have described the individual mortality risks from smoking and how these have evolved.1015 Others quantify the impact of smoking on national, regional and global mortality levels.1618 The sheer volume of death and disability attributable to tobacco underscores the importance of tobacco control as an urgent global health priority

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