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Repeated exposure to nicotine without interruption or challenge (quit attempts) provides continuous positive reinforcement for smoking behavior, strengthening the neural pathways associated with tobacco-seeking and tobacco-taking 27
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[45] found that e-cigs have a powerful booster effect on phase-I carcinogen-bioactivating enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), and increase oxygen free radical production and DNA oxidation to 8-hydroxy2'-deoxyguanosine
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These neurological impacts ultimately compromise workplace performance, decision-making capabilities, and professional productivity, with many organizations increasingly recognizing smoking cessation programs as strategic investments in employee cognitive performance and mental wellness
