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Manufacturers have invested heavily in flavor diversification, packaging modernization, and digital marketing initiatives to attract younger adult tobacco users who demonstrate lower affinity for traditional forms such as loose-leaf chewing tobacco or plug tobacco

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Acknowledgements Medical writing support, including assisting authors with the development of the outline and initial draft and incorporation of comments was provided by Fiona Van, Ph.D., and editorial support, formatting, proofreading, and submission was provided by Ian Norton, PhD, both of Scion, London, UK, supported by Bayer AG and Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA (MSD) according to Good Publication Practice guidelines ( The sponsor was involved in the study design, collection, analysis, and interpretation of the data, as well as data checking of information provided in the manuscript

Water content by NIR spectroscopy The water content of all STPs was measured by near-infrared (NIR) spectroscopy using a standard technique wherein water was extracted from the STPs using anhydrous methanol

Menthol cigarettes, flavored vape products, and most flavored nicotine pouches are no longer sold legally in California

5 in the UK