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Coca referred to another ingredient in Pembertons recipe: cocaine, derived from the coca plant of South America

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It has been known that CS-induced oxidative stress weakened GSH levels in airway epithelium and disrupted tight junctions, epithelial barrier integrity, finally leading to the impairment of epithelial barrier function [45, 46]

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Around a decade later, different calcium signatures could be imposed using a sequence of electrical pulses, and the plant response was then monitored by transcriptomics (Whalley and Knight 2013)