We identified 22 Cochrane systematic reviews on behavioural interventions, pharmacotherapies, combined behavioural and pharmacotherapy interventions, and other interventions.22 We updated our search in June 2024, and findings on benefits and harms were consistent with results from earlier searches (Appendix 2, available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)
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Fewer studies were quasi-experimental ( n = 124), with designs such as controlled before and after (14), before and after (2), interrupted time series (66) or other quasi-experimental approaches (42)
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