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A recent insert-based lung model incorporating epithelial-alveolar macrophage co-cultures have demonstrated that macrophages modulate epithelial cell function under cigarette smoke exposure, mimicking in vivo inflammatory dynamics and macrophage polarization shifts 10

AMERICAN LEGEND Application Number 004093258 Status Registered Filing Date 2004-10-27 Registration Date 2005-11-16 Owner KARELIA TOBACCO COMPANY INC (Greece) NICE Classes

Philosophical Transactions of the Royal Society of London

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The airway epithelium forms the first barrier to the inhaled environment, including noxious particles and gases, and plays a crucial role in host defense and maintaining lung homeostasis [3]

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