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Glucagon receptor activation: Increased hepatic glucose output under some conditions, increased energy expenditure, effects on hepatic lipid metabolism

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To restore ER homeostasis and reduce the number of misfolded or unfolded proteins in the ER, the unfolded protein response (UPR) is activated ( The ER stress response (UPR) is initiated and regulated by three ER sensors: inositol-requiring enzyme 1 (IRE1), double-stranded RNA-activated protein kinase R-like ER kinase (PERK), and activating transcription Factor 6 (ATF6) ( 2+ accumulation and lipid peroxidation are induced, thereby triggering ferroptosis (Zhao et al., 2021