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The PK profiles of intact AMG 133 (GIPR-Ab with at least one attached GLP-1 analogue peptide) and total AMG 133 (GIPR-Ab with or without GLP-1 analogue peptides) follow a biphasic clearance pattern and demonstrate similar initial concentrations between assays with a gradual divergence over the 2-week study period
10.1210/jcem.87.3.8355 93 NauckM
3c and Supplementary Table 2)
Moderate doses of alcohol also very quickly increase slow wave sleep (SWS) in the first half of an 8-hour sleep episode
If not, maybe staying on a low dose would be an okay trade-off for getting to enjoy this life phase at a weight Im more comfortable with
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