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The biggest anecdotally documented adverse effect of edibles is getting too high
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MAO-A is more dominant in the heart, platelets, gut, and certain neurons, while MAO-B is prevalent in astrocytes and specific brain regions, as well as in the heart, intestines, kidneys, and blood vessels.[ref][ref][ref] Variants in the MAOA gene sometimes called the warrior gene can affect neurotransmitter levels and have been linked to changes in mood, aggressiveness, and response to antidepressants