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A 2023 review in Frontiers in Neuroendocrinology highlighted heterodimer formation between GHSR-1a and dopamine D1 receptors as a potentially significant mechanism for ghrelins CNS effects

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In the seaweed, this ratio is about 95:5, but commercial extraction under very mild alkaline conditions increases the theta content to about 10%, and maximizes the molecular weight of the extract, its primary functionality being as a thickener

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