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Stress conditions, such as DNA damage, hypoxia, nutrient deprivation or oncogene activation, lead to the inhibition of MDM2 and/or direct modification of p53, resulting in the stabilisation and thus activation of the p53 protein

When we look at the signatures from the marijuana smokers, they look closer to non-users and non-smokers than the tobacco smokers, and that was a surprise to us. These findings diverge from earlier cell culture studies, which showed that both tobacco and marijuana smoke generate significant oxidative stress and inflammation

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you cant overdose on naturally-derived cannabinoids alone even if you take too much

However, because of the pandemic, OPN collection of smoking consumption was paused in 2020 and 2021

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