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Further, given the known strong links between cigarette smoking and FEV1, 28 as well as with cerebrovascular disease, 1 covarying for FEV1 and Fazekas score might substantially control for the amount of smoking and hence overcontrol for the effect of interest, namely the possible impact of smoking on the cortex

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One prominent assumption was that the impact of COVID-19 varies depending on the individuals immunity and not on smoking status