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The EM structure of Tirzepatide bound to the complete GIPR and G-proteins (Figure 3, PDB ID 7rbt, Sun et al., 2022) shows some hydrophobic and some specific polar interactions between the peptidic drug and the GIP receptor molecule

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Tirzepatide: Tirzepatide, a dual GIP/GLP-1 agonist, represents a newer generation of metabolic peptides with potent weight loss effects through combined appetite suppression and metabolic enhancement

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