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The authors only looked at generally healthy individuals, excluding patients taking medication for cardiac related disorders, for example

[8] Vaping is different from smoking, but there are some similarities, including the hand-to-mouth action of smoking and an aerosol that looks like cigarette smoke

Recently the laws around e-cigarettes have changed, and more information on these changes is available here

Cigarette smoking among adultsUnited States, 2007

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Marlboro Reds nicotine content per stick is significant, making it a popular choice among smokers who prefer stronger options like those offered by PMI