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Generally, if you choose the filling and capping machine, you do not need to separately configure the capping machine

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Significance was determined with Student's t test and ANOVA

The choice of an interval of 45 minutes between baseline and second examination in group 1 and 3 was based on a general estimate of the time necessary to reach the peak plasmatic concentration of caffeine after oral assumption, but a considerable inter-individual variability in caffeine kinetics exists [34]

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A visual summary of the guideline is available in Figure 1